concept

MITOCHONDRIAL FISSION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MITOCHONDRIAL FISSION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

47Connections

1Hypotheses

2Analyses

15Outgoing

32Incoming

0Experiments

2Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	MITOCHONDRIAL FISSION

Pathway Diagram

graph TD
    MITOCHONDRIAL_FISSION["MITOCHONDRIAL FISSION"]
    MITOCHONDRIAL_FISSION -->|"causes"| Neuronal_Cell_Death["Neuronal Cell Death"]
    MITOCHONDRIAL_FISSION -->|"contributes to"| Tumor_Growth["Tumor Growth"]
    PGAM5["PGAM5"] -->|"regulates"| MITOCHONDRIAL_FISSION
    DLK["DLK"] -->|"activates"| MITOCHONDRIAL_FISSION
    GJA1_20k["GJA1-20k"] -->|"activates"| MITOCHONDRIAL_FISSION
    MAPK["MAPK"] -->|"activates"| MITOCHONDRIAL_FISSION
    DNM1L["DNM1L"] -->|"mediates"| MITOCHONDRIAL_FISSION
    DRP1["DRP1"] -->|"mediates"| MITOCHONDRIAL_FISSION
    ERK2["ERK2"] -->|"mediates"| MITOCHONDRIAL_FISSION

Outgoing (15)

Target	Relation	Type	Str
ATP depletion	causes	mechanism	0.90
Mitochondrial Life Cycle	promotes	process	0.90
Neuronal Cell Death	causes	phenotype	0.88
Mitophagy	contributes_to	process	0.88
Angiogenesis	contributes_to	process	0.85
mtDNA	causes	biomarker	0.85
Tumor Growth	contributes_to	phenotype	0.85
Pancreatic Ductal Adenocarcinoma	associated_with	disease	0.85
glycolysis	associated_with	pathway	0.85
Pancreatic Cancer	associated_with	disease	0.85
Glycolysis	correlates_with	pathway	0.85
mitochondrial respiration	associated_with	process	0.80
mPTP sensitivity	causes	phenotype	0.70
TDP-43 pathology	early_event	mechanism	0.70
mitochondrial dysfunction	causes	mechanism	0.70

Incoming (32)

Source	Relation	Type	Str
Plasmalogen biosynthesis	regulates	pathway	0.95
DLK	activates	gene	0.95
GJA1-20k	associated_with	protein	0.95
AMPK	promotes	protein	0.95
DNM1L	promotes	protein	0.92
DRP1	promotes	protein	0.90
GJA1-20k	activates	protein	0.90
HDAC3	promotes	gene	0.90
Axon Injury	associated_with	phenotype	0.90
DLK	drives	gene	0.90
DRP1	causes	protein	0.90
MAPK	activates	pathway	0.90
PGAM5	activates	protein	0.90
DRP1	mediates	protein	0.90
ERK2	mediates	protein	0.90
DNM1L	mediates	protein	0.90
TMEM189	regulates	gene	0.90
DRP1 Phosphorylation	associated_with	mechanism	0.90
PINK1	regulates	gene	0.88
Drp1	regulates	gene	0.85
Sevoflurane	associated_with	drug	0.85
DRP1	regulates	protein	0.85
Mt-125	inhibits	drug	0.85
DRP1	regulates	gene	0.85
Oxidative stress	activates	process	0.85
MT1	regulates	gene	0.80
Mdivi-1	inhibits	drug	0.80
DRP1	activates	protein	0.70
Amyloid-beta	modulates	protein	0.70
AMPK	activates	protein	0.70
high salt diet	inhibits	process	0.70
SIRT3	promotes	protein	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
DRP1 S616 Hyperphosphorylation and MFN2 Downregulation Creat	0.680	neurodegeneration	-

Mentioning Analyses (2)

Scientific analyses that reference this entity

Does tau aggregation specifically cause PS externalization in vesicles independe

neurodegeneration | 2026-04-11 | 0 hypotheses

What upstream mechanisms cause TDP-43 to trigger mPTP opening and can this be th

neurodegeneration | 2026-04-08 | 5 hypotheses Top: 0.693

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

While the study demonstrates TDP-43 triggers mPTP-mediated mtDNA release, the mo

closed · Rounds: 4 · Score: 0.77 · 2026-04-21

The debate revealed a fundamental gap in understanding whether tau pathology dir

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Related Research

Hypotheses and analyses mentioning MITOCHONDRIAL FISSION in their description or question text

No additional research found