Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MC4R: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
MC4R gene encoding the melanocortin 4 receptor - critical for energy homeostasis, appetite regulation, and metabolic function
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| Gene Symbol | MC4R |
| Full Name | Melanocortin 4 Receptor |
| Aliases | MC4R gene encoding the melanocortin 4 receptor |
| Chromosome | 18q21.3 |
| Protein Type | Receptor |
| Function | encodes a G protein-coupled receptor (GPCR) that plays a critical role in energy homeostasis, appetite regulation, and metabolic function. |
| Primary Expression | the central nervous system and regulates food intake, energy expenditure, and body weight |
| Molecular Weight | 37 kDa |
| Amino Acids | 332 aa |
| UniProt ID | P32246 |
| NCBI Gene ID | 4162 |
| Ensembl ID | ENSG00000137273 |
| OMIM | 601665 |
| GeneCards | MC4R |
| Human Protein Atlas | MC4R |
| Associated Diseases | Als, neurodegeneration, Obesity |
| Interactions | BDNF, CNR1, DRD1, GABA, HDAC6, NLRP3 |
| KG Connections | 36 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
MC4R["MC4R"]
Als{"Als"}
MC4R -->|"associated with"| Als
Obesity{"Obesity"}
MC4R -->|"associated with"| Obesity
MC4R -->|"inhibits"| Als
MC4R -->|"inhibits"| Obesity
GENES["GENES"]
MC4R -->|"associated with"| GENES
ACHE["ACHE"]
MC4R -->|"associated with"| ACHE
neurodegeneration["neurodegeneration"]
MC4R -->|"implicated in"| neurodegeneration
MAF["MAF"]
MAF -->|"associated with"| MC4R
HDAC6["HDAC6"]
HDAC6 -->|"inhibits"| MC4R
style MC4R fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Tumor | treats | disease | 0.65 |
| Senescence | treats | disease | 0.65 |
| Obesity | therapeutic_target | disease | 0.65 |
| Obesity | inhibits | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Obesity | associated_with | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| NR3C2 | causes | gene | 0.60 |
| IL-6 | treats | gene | 0.60 |
| CTNNB1 | treats | gene | 0.60 |
| NLRP3 | activates | gene | 0.60 |
| NLRP3 | causes | gene | 0.60 |
| neurodegeneration | causes | disease | 0.60 |
| neurodegeneration | activates | disease | 0.60 |
| GENES | associated_with | gene | 0.60 |
| ACHE | associated_with | gene | 0.60 |
| SHH | treats | gene | 0.60 |
| Checkpoint Inhibitor | treats | pathway | 0.60 |
| Wnt | treats | pathway | 0.60 |
| Mapk | treats | pathway | 0.60 |
| Angiogenesis | treats | pathway | 0.60 |
| Immune Checkpoint | treats | pathway | 0.60 |
| NR3C2 | activates | gene | 0.60 |
| neurons | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MC4R in their description or question text
No additional research found