gene

LEPR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LEPR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

22Connections

0Hypotheses

0Analyses

17Outgoing

5Incoming

0Experiments

0Debates

Summary

LEPR encodes the leptin receptor, a cytokine receptor critical for energy homeostasis, metabolism, and neuroendocrine function, with implications for Alzheimer's and Parkinson's diseases.

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🧬 Gene Info

Gene Symbol	LEPR
Full Name	Leptin Receptor
Chromosome	1p31.3
Protein Type	Receptor
Function	encodes a cytokine receptor family member that mediates the effects of leptin on energy homeostasis, metabolism, and neuroendocrine function.
Primary Expression	multiple tissues including the hypothalamus, pituitary, liver, and immune cells
Amino Acids	800 aa
Exons	20
Pathways	JAK-STAT signaling
UniProt ID	[P48471](https://www.uniprot.org/uniprot/P48471)
Ensembl ID	ENSG00000116678
GeneCards	LEPR
Human Protein Atlas	LEPR
Chromosomal location	1p31.3
Genomic span	~170 kb, 20 exons
Associated Diseases	neurodegeneration
Interactions	AKT, AMPK, ERK, IL10, IL6, JAK
KG Connections	22 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

LEPR — Leptin Receptor

gene · 1051 words

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Leptin Receptor (LEPR) Neurons

cell · 810 words

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Pathway Diagram

graph TD
    LEPR["LEPR"]
    Obesity{"Obesity"}
    LEPR -->|"regulates"| Obesity
    Ms{"Ms"}
    LEPR -->|"regulates"| Ms
    Als{"Als"}
    LEPR -->|"expressed in"| Als
    ERK["ERK"]
    LEPR -->|"activates"| ERK
    AKT["AKT"]
    LEPR -->|"activates"| AKT
    PI3K["PI3K"]
    LEPR -->|"activates"| PI3K
    Pi3K(["Pi3K"])
    LEPR -->|"activates"| Pi3K
    Akt(["Akt"])
    LEPR -->|"activates"| Akt
    neurodegeneration["neurodegeneration"]
    LEPR -->|"implicated in"| neurodegeneration
    AMPK["AMPK"]
    AMPK -->|"activates"| LEPR
    AKT -->|"activates"| LEPR
    ERK -->|"activates"| LEPR
    JAK["JAK"]
    JAK -->|"activates"| LEPR
    AND["AND"]
    AND -->|"regulates"| LEPR
    style LEPR fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (17)

Target	Relation	Type	Str
AKT	activates	gene	0.70
PI3K	activates	gene	0.70
Obesity	regulates	disease	0.65
Ms	regulates	disease	0.65
Als	expressed_in	disease	0.65
Als	activates	disease	0.65
Mtor	activates	pathway	0.60
Pi3K/Akt	activates	pathway	0.60
Insulin Signaling	activates	pathway	0.60
MTOR	activates	gene	0.60
ERK	activates	gene	0.60
Pi3K	activates	pathway	0.60
Akt	activates	pathway	0.60
STAT3	inhibits	gene	0.60
IL6	inhibits	gene	0.60
JAK2	inhibits	gene	0.60
IL10	activates	gene	0.60

Incoming (5)

Source	Relation	Type	Str
AMPK	activates	gene	0.60
ERK	activates	gene	0.60
JAK	activates	gene	0.60
PTEN	activates	gene	0.60
AKT	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LEPR in their description or question text

No additional research found