| Gene Symbol | LEPR |
| Full Name | Leptin Receptor |
| Chromosome | 1p31.3 |
| Protein Type | Receptor |
| Function | encodes a cytokine receptor family member that mediates the effects of leptin on energy homeostasis, metabolism, and neuroendocrine function. |
| Primary Expression | multiple tissues including the hypothalamus, pituitary, liver, and immune cells |
| Amino Acids | 800 aa |
| Exons | 20 |
| Pathways | JAK-STAT signaling |
| UniProt ID | [P48471](https://www.uniprot.org/uniprot/P48471) |
| Ensembl ID | ENSG00000116678 |
| GeneCards | LEPR |
| Human Protein Atlas | LEPR |
| Chromosomal location | 1p31.3 |
| Genomic span | ~170 kb, 20 exons |
| Associated Diseases | neurodegeneration |
| Interactions | AKT, AMPK, ERK, IL10, IL6, JAK |
| KG Connections | 22 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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