gene

KIF4A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KIF4A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

40Connections

0Hypotheses

0Analyses

22Outgoing

18Incoming

0Experiments

0Debates

Summary

Gene profile: KIF4A, a kinesin motor protein critical for axonal transport and synaptic function in neurodegeneration

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🧬 Gene Info

Gene Symbol	KIF4A
Full Name	Kinesin Family Member 4A
Chromosome	Xq13.1
Protein Family	Kinesin-4 family
Function	is a major axonal transport motor essential for neuronal function
Primary Expression	Brain (neurons), proliferating cells
Molecular Weight	140 kDa
Amino Acids	1232 aa
Exons	23
Pathways	Cell Cycle, Epithelial-Mesenchymal Transition, ferroptosis
UniProt ID	O95239
NCBI Gene ID	22937
GeneCards	KIF4A
Human Protein Atlas	KIF4A
N-terminal motor domain (1-400 aa)	Contains the catalytic core with microtubule-binding site and ATPase activity
Associated Diseases	glioblastoma
Interactions	AND, CANCER, CD8, CHMP4B, FERROPTOSIS, GBM
KG Connections	40 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KIF4A — AlphaFold O95239 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

KIF4A — Kinesin Family Member 4A

gene · 2012 words

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Pathway Diagram

graph TD
    KIF4A["KIF4A"]
    Als{"Als"}
    KIF4A -->|"interacts with"| Als
    Ms{"Ms"}
    KIF4A -->|"interacts with"| Ms
    Cancer{"Cancer"}
    KIF4A -->|"interacts with"| Cancer
    Tumor{"Tumor"}
    KIF4A -->|"interacts with"| Tumor
    JUN["JUN"]
    KIF4A -->|"associated with"| JUN
    neurodegeneration["neurodegeneration"]
    KIF4A -->|"implicated in"| neurodegeneration
    KIF20A["KIF20A"]
    KIF20A -->|"associated with"| KIF4A
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"interacts with"| KIF4A
    CD8["CD8"]
    CD8 -->|"interacts with"| KIF4A
    HSP90AB1["HSP90AB1"]
    HSP90AB1 -->|"associated with"| KIF4A
    CANCER["CANCER"]
    CANCER -->|"interacts with"| KIF4A
    style KIF4A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (22)

Target	Relation	Type	Str
Ferroptosis	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Tumor	activates	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
glioblastoma	targets	disease	0.60
GBM	activates	gene	0.60
Epithelial	activates	cell_type	0.60
glioblastoma	activates	disease	0.60
glioblastoma	associated_with	disease	0.60
CHMP4B	interacts_with	protein	0.60
Cell Cycle	activates	pathway	0.60
JUN	associated_with	gene	0.60
CHMP4B	activates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
ROS	activates	gene	0.60
ferroptosis	participates_in	pathway	0.60
ferroptosis	activates	phenotype	0.50
Epithelial-Mesenchymal Transition	activates	process	0.50
Glioma	interacts_with	disease	0.50

Incoming (18)

Source	Relation	Type	Str
CANCER	interacts_with	gene	0.60
AND	activates	gene	0.60
KIF20A	associated_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
CD8	interacts_with	gene	0.60
HSP90AB1	associated_with	gene	0.60
GBM	associated_with	gene	0.60
GBM	targets	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
ROS	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
CHMP4B	activates	gene	0.50
GBM	activates	gene	0.50
GPX4	activates	gene	0.50
CHMP4B	associated_with	gene	0.50
GBM	co_expressed_with	gene	0.50
GPX4	co_expressed_with	gene	0.50
WAS	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity