gene 2,092 words KG: HNRNPUL2
Contents

HNRNPUL2 Gene

🧬 Gene Info
Gene SymbolHNRNPUL2
Chromosome19q13.43
Functionis a nuclear matrix protein that belongs to the hnRNP U family.
Primary Expressionhuman tissues, with particularly high expression in neuronal nuclei
Amino Acids640 aa
GeneCardsHNRNPUL2
Human Protein AtlasHNRNPUL2
N-terminal SAP domainInvolved in DNA/RNA binding and nuclear matrix attachment
Central glycine-rich regionFacilitates protein-protein interactions
C-terminal RGG repeatsRNA-binding motifs involved in RNA granule formation
Alternative splicing regulationModulates inclusion or exclusion of specific exons
RNA stabilityBinds to specific RNA sequences to regulate mRNA half-life
RNA transportFacilitates transport of mRNAs from nucleus to cytoplasm
BrainParticularly in the cerebral cortex, hippocampus, and spinal cord motor neurons
TestisHigh expression in spermatogonia and spermatocytes
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (8)

Cross-Seeding Prevention Strategy
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Cryptic Exon Silencing Restoration
Score: 0.53
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47
Circadian Clock-Autophagy Synchronization
Score: 0.76
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
Axonal RNA Transport Reconstitution
Score: 0.70
Temporal Decoupling via Circadian Clock Reset
Score: 0.54

Related Analyses (7)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
mitochondrial-dysfunction-neurodegeneration-comparison
disease · Pages share 4 hypotheses
Familial vs Sporadic Neurodegeneration Comparison
disease · Pages share 4 hypotheses
UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 4 hypotheses
TARDBP Mutations in Amyotrophic Lateral Sclerosis
disease · Pages share 4 hypotheses

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