Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HNRNP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | HNRNP |
| Function | HNRNP-A2B1 (Heterogeneous Nuclear Ribonucleoprotein A2/B1) is an RNA-binding protein that plays essential roles in RNA splicing, transport, and translation[^1]. |
| Subcellular Localization | signal:** Basic region for nuclear import ## Normal Function HNRNP-A2B1 perfor |
| Pathways | Brain Development, Gene Expression Regulation, Neurodevelopmental Development, RNA processing, neuronal function |
| GeneCards | HNRNP |
| Human Protein Atlas | HNRNP |
| Associated Diseases | neurodevelopmental delay, Neurodevelopmental Disorders |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
HNRNP(["HNRNP"])
style HNRNP fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
Neurodevelopmental_Disorders(["Neurodevelopmental Disorders"])
Neurodevelopmental_Development(["Neurodevelopmental Development"])
Brain_Development(["Brain Development"])
Gene_Expression_Regulation(["Gene Expression Regulation"])
HNRNP -->|"causes"| Neurodevelopmental_Disorders
HNRNP -->|"risk_factor_for"| Neurodevelopmental_Disorders
HNRNP -->|"involved_in"| Neurodevelopmental_Development
HNRNP -->|"involved_in"| Brain_Development
HNRNP -->|"involved_in"| Gene_Expression_Regulation
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
class Neurodevelopmental_Disorders protein
class Neurodevelopmental_Development protein
class Brain_Development protein
class Gene_Expression_Regulation protein| Target | Relation | Type | Str |
|---|---|---|---|
| Neurodevelopmental Disorders | causes | disease | 0.95 |
| pre-mRNA splicing | mediates | process | 0.92 |
| neurodevelopmental delay | implicated_in | phenotype | 0.90 |
| Neurodevelopmental Disorders | risk_factor_for | disease | 0.90 |
| RNA processing | involved_in | process | 0.85 |
| Neurodevelopmental Development | involved_in | process | 0.85 |
| Brain Development | involved_in | process | 0.82 |
| brain development | contributes_to | process | 0.80 |
| neuronal function | regulates | process | 0.75 |
| Gene Expression Regulation | involved_in | process | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AGER | associated_with | gene | 0.30 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| hnRNPA2B1-Mediated Structural Remodeling Controls lncRNA-002 | 0.684 | molecular neurobiology | View |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning HNRNP in their description or question text
No additional research found