Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BRAIN DEVELOPMENT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | BRAIN DEVELOPMENT |
graph TD
BRAIN_DEVELOPMENT[BRAIN DEVELOPMENT]
BRAIN_DEVELOPMENT -->|correlates_with| Neurocognitive_Function[Neurocognitive Function]
Epigenetic_Reconfiguration[Epigenetic Reconfiguration] -->|involved_in| BRAIN_DEVELOPMENT
Epigenomic_Reconfiguration[Epigenomic Reconfiguration] -->|involved_in| BRAIN_DEVELOPMENT
HDAC3[HDAC3] -->|regulates| BRAIN_DEVELOPMENT
epigenomic_reconfiguration[epigenomic reconfiguration] -->|regulates| BRAIN_DEVELOPMENT
Angiogenesis[Angiogenesis] -->|involved_in| BRAIN_DEVELOPMENT
DNA_METHYLATION[DNA METHYLATION] -->|involved_in| BRAIN_DEVELOPMENT
CHROMATIN[CHROMATIN] -->|involved_in| BRAIN_DEVELOPMENT
Brain_Macrophages[Brain Macrophages] -->|involved_in| BRAIN_DEVELOPMENT
Chromatin[Chromatin] -->|involved_in| BRAIN_DEVELOPMENT
estrogen_signaling[estrogen signaling] -->|modulates| BRAIN_DEVELOPMENT| Target | Relation | Type | Str |
|---|---|---|---|
| Neurocognitive Function | correlates_with | phenotype | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| epigenomic reconfiguration | regulates | process | 0.95 |
| HDAC3 | regulates | gene | 0.95 |
| Epigenetic Reconfiguration | involved_in | process | 0.95 |
| Angiogenesis | involved_in | process | 0.95 |
| Epigenomic Reconfiguration | involved_in | process | 0.95 |
| CHROMATIN | involved_in | structure | 0.90 |
| DNA METHYLATION | involved_in | entity | 0.90 |
| Brain Macrophages | involved_in | cell_type | 0.88 |
| estrogen signaling | modulates | pathway | 0.85 |
| Histone Deacetylases | regulates | enzyme | 0.85 |
| Epigenetic Mechanisms | regulates | mechanism | 0.85 |
| Microglia | involved_in | cell_type | 0.85 |
| Chromatin | involved_in | structure | 0.85 |
| OCN | involved_in | protein | 0.85 |
| HNRNP | involved_in | gene | 0.82 |
| HNRNP | contributes_to | protein | 0.80 |
| CNS Macrophages | involved_in | cell_type | 0.75 |
| 21030649 | are associated with | paper | 0.60 |
| 21030649 | associated with | paper | 0.60 |
| SRPK1 | involved_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning BRAIN DEVELOPMENT in their description or question text
No additional research found