gene 1,567 words KG: HNRNPF
Contents

HNRNPF Gene

🧬 Gene Info
Gene SymbolHNRNPF
Chromosome10q11.22
Functionis an RNA-binding protein encoding gene located on chromosome 10q11.
Subcellular Localizationand protein interactions. [@geuens2016]
Molecular Weight46 kDa
Amino Acids415 aa
Exons11
GeneCardsHNRNPF
Human Protein AtlasHNRNPF
RRM1 (N-terminal)Primary RNA-binding domain with high affinity for G-rich sequences
RRM2 (Central)Contributes to RNA binding specificity
RRM3 (C-terminal)Facilitates protein-protein interactions
Isoform 1Full-length protein (415 aa) - predominant form
Isoform 2Alternative exon inclusion (387 aa)
Isoform 3Truncated form with alternative C-terminus
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (5)

Cross-Seeding Prevention Strategy
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Cryptic Exon Silencing Restoration
Score: 0.53
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47
APOE-Dependent Autophagy Restoration
Score: 0.88

Related Analyses (5)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
mitochondrial-dysfunction-neurodegeneration-comparison
disease · Pages share 4 hypotheses
Familial vs Sporadic Neurodegeneration Comparison
disease · Pages share 4 hypotheses
UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 4 hypotheses
TARDBP Mutations in Amyotrophic Lateral Sclerosis
disease · Pages share 4 hypotheses

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