gene

HLA-A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HLA-A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

20Connections

0Hypotheses

0Analyses

13Outgoing

7Incoming

0Experiments

0Debates

Summary

HLA class I gene involved in immune surveillance, antigen presentation, and neurodegenerative disease risk

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🧬 Gene Info

Gene Symbol	HLA
Primary Expression	Ca1, Cortex
Pathways	Jak-Stat, Apoptosis, Necroptosis, Epigenetic, Immune Response
GeneCards	HLA
Human Protein Atlas	HLA
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, Cardiovascular
Interactions	ABCA7, AGER, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOE
KG Connections	291 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

HLA-A — Major Histocompatibility Complex Class I A

gene · 1759 words

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Pathway Diagram

graph TD
    HLA_A["HLA-A"]
    HLA_A -->|"interacts"| Cancer["Cancer"]
    HLA_A -->|"interacts"| Tumor["Tumor"]
    HLA_A -->|"interacts"| P53["P53"]
    HLA_A -->|"interacts"| HLA["HLA"]
    HLA_A -->|"interacts"| AND["AND"]
    HLA_A -->|"interacts"| GENES["GENES"]
    HLA_A -->|"target for"| T_Cell["T Cell"]
    CANCER["CANCER"] -->|"interacts"| HLA_A
    TUMOR_SUPPRESSOR_GENES["TUMOR SUPPRESSOR GENES"] -->|"interacts"| HLA_A
    P53 -->|"interacts"| HLA_A
    TP53["TP53"] -->|"interacts"| HLA_A

Outgoing (13)

Target	Relation	Type	Str
Neurodegeneration	promotes	phenotype	0.90
MAPT	modulates	gene	0.88
Neuron	expressed_in	cell_type	0.88
Cancer	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
T Cell	therapeutic_target	cell_type	0.60
App	therapeutic_target	protein	0.60
P53	interacts_with	gene	0.60
HLA	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
T Cell	expressed_in	cell_type	0.55
TP53	interacts_with	gene	0.50

Incoming (7)

Source	Relation	Type	Str
APOE	upregulates	gene	0.92
TP53	binds	gene	0.80
CSNK1D	associated_with	gene	0.70
CANCER	interacts_with	gene	0.60
TUMOR SUPPRESSOR GENES	interacts_with	gene	0.60
P53	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HLA-A in their description or question text

No additional research found