| Gene Symbol | HFE |
| Aliases | Page for HFE Protein |
| Chromosome | 6p22.2 |
| Function | The HFE gene encodes a 348-amino acid transmembrane protein that is structurally related to major histocompatibility complex (MHC) class I proteins |
| Primary Expression | various brain regions including cortex, hippocampus, basal ganglia |
| Subcellular Localization | </th><td>Cell membrane, Endoplasmic reticulum</td></tr> |
| Molecular Weight | 40 kDa |
| Amino Acids | 348 aa |
| Pathways | Endocytosis |
| Ensembl ID | ENSG00000070010 |
| GeneCards | HFE |
| Human Protein Atlas | HFE |
| MHC-like fold | HFE shares the characteristic MHC class I three-domain structure. |
| Beta-2-microglobulin binding | Required for proper folding and cell surface expression. |
| Transferrin receptor interaction site | The alpha-1 and alpha-2 domains mediate binding to TfR1. |
| Associated Diseases | Als |
| Interactions | CAT, GSK3, TFR1 |
| KG Connections | 41 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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