gene 871 words KG: GFRAL
Contents

GFRAL Gene - GDNF Receptor Alpha Like

🧬 Gene Info
Gene SymbolGFRAL
Full NameGDNF Receptor Alpha Like
AliasesPage for GFRAL Gene, Page for GFRAL Protein
Chromosome6p12.1
Protein TypeReceptor
Functionis a cell surface receptor that belongs to the GDNF receptor family (GFRα).
Primary Expressionspecific neuronal populations: - Substantia nigra pars compacta: Dopaminergic neurons - Ventral tegmental area: Mesolimbic dopamine neurons -
Molecular Weight50 kDa
PathwaysPI3K
UniProt IDQ6UXB5
NCBI Gene ID390538
Ensembl IDENSG00000173137
OMIM615866
GeneCardsGFRAL
Human Protein AtlasGFRAL
Associated DiseasesALS
InteractionsADCY3, AND, CANCER, CYTOKINES, GDF15, Gdnf
KG Connections79 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (7)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Vagal Afferent Microbial Signal Modulation
Score: 0.62
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (8)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed

See Also (5)

GDNF (Redirect)
redirect · KG edge: associated_with
ADCY3 — Adenylate Cyclase 3
gene · KG edge: activates
BDNF Gene
gene · KG edge: activates
Autoimmune Hypothesis in Alzheimer's Disease
hypothesis · KG edge: therapeutic_target
Packard Center for ALS Research
institution · KG edge: activates

Knowledge Graph (12 edges)

GLP1R inhibits GFRAL
GFRAL inhibits GDNF
GDNF inhibits GFRAL
GFRAL contributes_to BDNF
GFRAL inhibits GLP1R
HDAC6 activates GFRAL
GDNF regulates GFRAL
SHH activates GFRAL
GFRAL activates ADCY3
GFRAL expressed_in Brainstem

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