Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GDAP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GDAP1 encodes a mitochondrial outer membrane protein critical for mitochondrial fission, peripheral nerve integrity, and neuronal survival. Mutations cause Charcot-Marie-Tooth disease.
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| Gene Symbol | GDAP1 |
| Full Name | Ganglioside-Induced Differentiation-Associated Protein 1 |
| Chromosome | 8q21.11 |
| Protein Family | Mitochondrial fission proteins |
| Function | encodes a mitochondrial outer membrane protein that plays a critical role in regulating mitochondrial dynamics, particularly mitochondrial fission. |
| Subcellular Localization | the mitochondrial outer membrane. The protein contains several functional domains: |
| Molecular Weight | 41 kDa |
| Amino Acids | 401 aa |
| Pathways | Autophagy, Mitophagy |
| UniProt ID | Q9UPN3 |
| NCBI Gene ID | 78986 |
| Ensembl ID | ENSG00000104381 |
| OMIM | 607706 |
| GeneCards | GDAP1 |
| Human Protein Atlas | GDAP1 |
| Associated Diseases | Autosomal Recessive Ataxia, Neuropathy, Peripheral Neuropathy |
| Interactions | AND, AUTOPHAGY, BCL2, BNIP3, BNIP3L, MITOPHAGY |
| KG Connections | 24 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GDAP1["GDAP1"]
Als{"Als"}
GDAP1 -->|"regulates"| Als
Neuropathy{"Neuropathy"}
GDAP1 -->|"associated with"| Neuropathy
Ms{"Ms"}
GDAP1 -->|"contributes to"| Ms
AUTOPHAGY["AUTOPHAGY"]
GDAP1 -->|"contributes to"| AUTOPHAGY
TFEB["TFEB"]
GDAP1 -->|"activates"| TFEB
LC3["LC3"]
GDAP1 -->|"contributes to"| LC3
Autophagy(["Autophagy"])
GDAP1 -->|"contributes to"| Autophagy
neurodegeneration["neurodegeneration"]
GDAP1 -->|"implicated in"| neurodegeneration
MOTOR_NEURONS["MOTOR NEURONS"]
MOTOR_NEURONS -->|"contributes to"| GDAP1
style GDAP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Peripheral Neuropathy | causes | disease | 0.95 |
| Autosomal Recessive Ataxia | causes | disease | 0.80 |
| Neuropathy | associated_with | disease | 0.65 |
| Neuropathy | activates | disease | 0.65 |
| Ms | contributes_to | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Autophagy | activates | pathway | 0.60 |
| TFEB | activates | gene | 0.60 |
| Mitophagy | activates | pathway | 0.60 |
| LC3 | contributes_to | gene | 0.60 |
| AUTOPHAGY | contributes_to | gene | 0.60 |
| Autophagy | contributes_to | pathway | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| MITOPHAGY | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| MFSD8 | associated_with | gene | 0.60 |
| SETX | associated_with | gene | 0.60 |
| AND | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BCL2 | activates | gene | 0.60 |
| BNIP3 | activates | gene | 0.60 |
| BNIP3L | activates | gene | 0.60 |
| MOTOR NEURONS | contributes_to | gene | 0.60 |
| AFG3L2 | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GDAP1 in their description or question text
No additional research found