Contents

Sepiapterin Reductase (SPR)

🔬 Protein Info

Gene Symbol	SPR
Protein Type	Enzyme
Function	GTP cyclohydrolase I (GCH1): GTP → 7,8-dihydroneopterin triphosphate
Subcellular Localization	Cytosolic
Pathways	Immune Response
Ensembl ID	ENSG00000166347
GeneCards	SPR
Human Protein Atlas	SPR
1QPD	Saccharomyces cerevisiae SPR complexed with NADPH (2.0 Å resolution) — reveals cofactor binding mode
1ZTR	Human SPR in complex with cofactor and inhibitor analogs (1.8 Å) — guides drug design
2NBQ	Mutant SPR variants from SRD patients — structure-function relationships
AlphaFold2	Predicted full-length human SPR structure consistent with biochemical data
Associated Diseases	ALS, Ischemia, Ms
Interactions	AKT1, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOPTOSIS, App
KG Connections	249 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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Knowledge Graph

TNF inhibits SPR

SPR inhibits HK2

SOD2 associated_with SPR

CAT associated_with SPR

BAX associated_with SPR

SPR associated_with PPARGC1A

SPR associated_with CASP3

SPR associated_with PDK1

SPR associated_with PDK4

SPR associated_with SOD1