protein 610 words KG: IRAK4
Contents

IRAK4 Protein

🔬 Protein Info
Gene SymbolIRAK4
Chromosome15q15.4
Protein FamilyIL-1 receptor-associated kinases
Protein TypeSerine/Threonine Kinase
FunctionIRAK4 is a serine/threonine kinase essential for TLR/IL-1R signaling.
Molecular Weight52 kDa
Amino Acids460 aa
PathwaysNF-κB, MAPK signaling, NF-κB signaling, NF-κB pathway, NF-κB Signaling
UniProt IDQ9NWZ3
GeneCardsIRAK4
Human Protein AtlasIRAK4
Associated Diseasesneurodegeneration
InteractionsApp, CSF2, CYTOKINES, HMGB1, IKK, Il-1
KG Connections44 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (5)

Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

mTOR Signaling Dysregulation in Progressive Supranuclea
event · KG edge: debate_co_mention
CSF2 — Colony Stimulating Factor 2 (GM-CSF)
gene · KG edge: activates
IL1A — Interleukin 1 Alpha
gene · KG edge: activates
IL1B Gene - Interleukin 1 Beta
gene · KG edge: activates
IRF3 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

IRAK4 expressed_in TAB1
IRAK4 expressed_in RELA
IL1B activates IRAK4
IRAK4 activates CSF2
IRAK4 activates IL1A
IRAK4 activates IRF3
IRAK4 activates TAK1
IRAK4 activates TLR4
IRAK4 activates TRAF6
APOE debate_co_mention IRAK4

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