| Gene Symbol | IRAK4 |
| Chromosome | 15q15.4 |
| Protein Family | IL-1 receptor-associated kinases |
| Protein Type | Serine/Threonine Kinase |
| Function | IRAK4 is a serine/threonine kinase essential for TLR/IL-1R signaling. |
| Molecular Weight | 52 kDa |
| Amino Acids | 460 aa |
| Pathways | NF-κB, MAPK signaling, NF-κB signaling, NF-κB pathway, NF-κB Signaling |
| UniProt ID | Q9NWZ3 |
| GeneCards | IRAK4 |
| Human Protein Atlas | IRAK4 |
| N-terminal Death Domain (DD) | Mediates interactions with MyD88 adaptor protein |
| Intermediate domain | Connects DD to kinase domain |
| Kinase Domain (KD) | Catalytic domain with serine/threonine kinase activity (active, unlike IRAK2/3) |
| Active kinase | Unlike IRAK2 and IRAK3, IRAK4 has demonstrable kinase activity |
| Associated Diseases | neurodegeneration |
| Interactions | App, CSF2, CYTOKINES, HMGB1, IKK, Il-1 |
| KG Connections | 44 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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