Contents

IKK Protein

🔬 Protein Info

Gene Symbol	IKK
Aliases	IKKPROTEIN
Function	Ikk Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Subcellular Localization	to Cytoplasm; nucleus upon activation and plays a significant role in the pathog
Molecular Weight	87 kDa
Pathways	NF-κB, NF-κB pathway
GeneCards	IKK
Human Protein Atlas	IKK
IκB phosphorylation	Phosphorylates IκBα at Ser32/36, leading to ubiquitination and degradation
Canonical NF-κB pathway	Mediates classical NF-κB activation by TNF-α, IL-1, and pathogens
Signal transduction	Converts extracellular signals into nuclear gene expression
Inflammatory response	Controls cytokine, chemokine, and adhesion molecule expression
Cell survival	NF-κB target genes include anti-apoptotic proteins (Bcl-2, XIAP)
Immune cell activation	Essential for B cell, T cell, and macrophage function
Stress response	Activated by genotoxic stress, ROS, and viral infection
Associated Diseases	ALS, Alzheimer, Parkinson
Known Drugs/Compounds	metformin, rapamycin
Interactions	ACC, ASC, ATG, BECN1, BRG1, CCDC50
KG Connections	80 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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