| Gene Symbol | GSTM1 |
| Full Name | Glutathione S-Transferase Mu 1 |
| Chromosome | 1p13.3 |
| Protein Type | Enzyme |
| Function | GSTM1 (Glutathione S-Transferase Mu 1) encodes a member of the glutathione S-transferase (GST) family of enzymes that catalyze the conjugation of glutathione (GSH) to a wide variety of endogenous and |
| Subcellular Localization | ** | Cytoplasm (predominant), mitochondria | |
| Molecular Weight | 26 kDa |
| Amino Acids | 218 aa |
| Pathways | Notch, Telomere |
| UniProt ID | [P09488](https://www.uniprot.org/uniprot/P09488) |
| Ensembl ID | ENSG00000166736 |
| GeneCards | GSTM1 |
| Human Protein Atlas | GSTM1 |
| N-Terminal Domain (G-site, aa 1-80) | Contains the glutathione (GSH) binding site that recognizes and binds the tripeptide GSH with high affinity. Key residues include Tyr6 and Gln67 that form hydrogen bonds with GSH. |
| C-Terminal Domain (H-site, aa 90-218) | The hydrophobic substrate binding site that accommodates a wide range of electrophilic substrates. This domain determines the substrate specificity of GSTM1. |
| Associated Diseases | neurodegeneration |
| Interactions | APC, GENES, MYC, P53, RAS |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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