| Gene Symbol | GSK3B |
| Aliases | GSK-3β, TPKII, Tau tubulin kinase (TTBK) |
| Chromosome | 3q13.33 |
| Protein Type | Serine/Threonine Kinase |
| Function | is a constitutively active serine/threonine kinase encoded by the GSK3B gene that plays central and multifaceted roles in cellular physiology[@woodgett1990]. |
| Subcellular Localization | </th><td>Cytoplasm, Nucleus, Mitochondria, Synapse</td></tr> |
| Molecular Weight | 47 kDa (420 amino acids) |
| Amino Acids | 420 aa |
| Exons | 12 |
| Pathways | Akt, Cholesterol, Mapk, Microrna, Nf-Kb |
| GeneCards | GSK3B |
| Human Protein Atlas | GSK3B |
| O-GlcNAcylation | Cross-talk with phosphorylation mechanisms |
| Sumoylation | Affects subcellular localization and stability |
| Oxidative modifications | Activity modulated by cellular redox state |
| Associated Diseases | Aging, ALS, Alzheimer, Alzheimer's disease, APOPTOSIS |
| Known Drugs/Compounds | ANTHOCYANINS, Ficus deltoidea, LITHIUM, rapamycin, RAPAMYCIN, SB216763 |
| Interactions | ABCA1, ACETYL-COA, ACHE, Actin, AD, ADAM17 |
| KG Connections | 1182 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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