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protein 1,398 words KG: GDNF
Contents

Glial Cell Derived Neurotrophic Factor (GDNF)

🔬 Protein Info
Gene SymbolGDNF
AliasesGlial Cell Line-Derived Neurotrophic Factor
Protein FamilyGDNF family (TGF-β superfamily)
FunctionMaintains tyrosine hydroxylase expression
Primary ExpressionSecreted, Extracellular space
Subcellular LocalizationSecreted, Extracellular space
Molecular Weight15 kDa
PathwaysPI3K, MAPK, TGF-β
UniProt IDP39905
GeneCardsGDNF
Human Protein AtlasGDNF
Associated DiseasesAls, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety, CYTOKINES
Known Drugs/Compoundslevodopa, rapamycin, trehalose
InteractionsACLY, ADCY3, AKT, ALOX15, ALPHA-SYNUCLEIN, ALZHEIMER
SciDEX HypothesesGDNF Gradient Establishment by Schwann Cells Enabl
KG Connections733 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (70)

Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74Phase-Separated Organelle Targeting
Score: 0.73Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71HDAC3-Selective Inhibition for Clock Reset
Score: 0.71TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70Extracellular Matrix Stiffness Modulation
Score: 0.69Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.68RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
← Prevpg 3/4Next →

Related Analyses (26)

CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · completedDigital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archivedSenolytic therapy for age-related neurodegeneration
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (4)

Selective Vulnerability of Dopaminergic Neurons — Mechanism
validation · proposed · Score: 0.40ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Cytochrome Therapeutics
clinical · proposed · Score: 0.40Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40

See Also (6)

ABCA7 (Redirect)
redirect · KG edge: associated_withacetylcholine
general · KG edge: co_discussedADCY3 — Adenylate Cyclase 3
gene · KG edge: activatesAlzheimer Indonesia
institution · KG edge: activatesPackard Center for ALS Research
institution · KG edge: associated_with

Knowledge Graph (12 edges)

BDNF inhibits GDNF
GLP1R inhibits GDNF
GFRAL inhibits GDNF
GDNF inhibits Dopamine
GDNF activates Dopamine
GDNF interacts_with Dopamine
Dopamine interacts_with GDNF
GDNF therapeutic_target Dopamine
GDNF inhibits GFRAL
GDNF inhibits BDNF

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