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protein 1,398 words KG: GDNF
Contents

Glial Cell Derived Neurotrophic Factor (GDNF)

🔬 Protein Info
Gene SymbolGDNF
AliasesGlial Cell Line-Derived Neurotrophic Factor
Protein FamilyGDNF family (TGF-β superfamily)
FunctionMaintains tyrosine hydroxylase expression
Primary ExpressionSecreted, Extracellular space
Subcellular LocalizationSecreted, Extracellular space
Molecular Weight15 kDa
PathwaysPI3K, MAPK, TGF-β
UniProt IDP39905
GeneCardsGDNF
Human Protein AtlasGDNF
Associated DiseasesAls, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety, CYTOKINES
Known Drugs/Compoundslevodopa, rapamycin, trehalose
InteractionsACLY, ADCY3, AKT, ALOX15, ALPHA-SYNUCLEIN, ALZHEIMER
SciDEX HypothesesGDNF Gradient Establishment by Schwann Cells Enabl
KG Connections734 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (70)

Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63Quantum Coherence Disruption in Cellular Communication
Score: 0.63SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54Blood-Brain Barrier SPM Shuttle System
Score: 0.53Piezoelectric Nanochannel BBB Disruption
Score: 0.52
← Prevpg 4/4

Related Analyses (26)

CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · completedDigital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archivedSenolytic therapy for age-related neurodegeneration
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (4)

Selective Vulnerability of Dopaminergic Neurons — Mechanism
validation · proposed · Score: 0.40ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Cytochrome Therapeutics
clinical · proposed · Score: 0.40Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40

See Also (6)

ABCA7 (Redirect)
redirect · KG edge: associated_withacetylcholine
general · KG edge: co_discussedADCY3 — Adenylate Cyclase 3
gene · KG edge: activatesAlzheimer Indonesia
institution · KG edge: activatesPackard Center for ALS Research
institution · KG edge: associated_with

Knowledge Graph (12 edges)

BDNF inhibits GDNF
GLP1R inhibits GDNF
GFRAL inhibits GDNF
GDNF inhibits Dopamine
GDNF activates Dopamine
GDNF interacts_with Dopamine
Dopamine interacts_with GDNF
GDNF therapeutic_target Dopamine
GDNF inhibits GFRAL
GDNF inhibits BDNF

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