protein 1,287 words KG: CLUSTERIN
Contents

Clusterin (CLU / Apolipoprotein J)

🔬 Protein Info
Gene SymbolCLU
Full NameClusterin
AliasesPage for CLU Gene
Chromosome8p21.1.
Protein FamilyApolipoprotein / extracellular chaperone
FunctionIt binds to non-native, misfolded, or aggregation-prone proteins and maintains them in a soluble state suitable for subsequent processing (Wyatt et al., 2009)
Primary ExpressionSecreted (sCLU), cytoplasmic/nuclear (nCLU/iCLU)
Molecular Weight80 kDa
Amino Acids522 aa
Exons9
PathwaysApoptosis, Complement, Immune Response, Mitophagy
UniProt IDP10909
NCBI Gene ID1115
Ensembl IDENSG00000120885
OMIM185551
GeneCardsCLU
Human Protein AtlasCLU
Associated Diseasesaging, Als, Alzheimer, Alzheimer Disease
InteractionsAKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, Amyloid Beta, APOE
KG Connections281 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (52)

APOE-Mediated Synaptic Lipid Raft Stabilization
Score: 0.65
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
Cholesterol-CRISPR Convergence Therapy for Neurodegeneration
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.58
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43
← Prevpg 3/3

Related Analyses (25)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
s:** - Compare uptake with/without magnetic particles using
falsification · proposed · Score: 0.40

See Also (10)

Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
Astrocytes
entity · KG edge: activates
BACE1 (Redirect)
redirect · KG edge: activates
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: activates

Knowledge Graph (12 edges)

CLU regulates CLUSTERIN
PPARGC1A regulates CLUSTERIN
BAX activates CLUSTERIN
CLUSTERIN activates LC3
CLUSTERIN regulates PPARG
C1S regulates CLUSTERIN
CLUSTERIN activates C1Q
CLUSTERIN regulates CR1
CLUSTERIN associated_with CFH
PPARG regulates CLUSTERIN

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