protein 2,786 words KG: CLUSTERINPROTEIN
Contents

Clusterin Protein

🔬 Protein Info
Gene SymbolCLU
Full NameClusterin
AliasesPage for CLU Gene
Chromosome8p21.1.
Protein FamilyApolipoprotein / extracellular chaperone
FunctionIt binds to non-native, misfolded, or aggregation-prone proteins and maintains them in a soluble state suitable for subsequent processing (Wyatt et al., 2009)
Primary ExpressionSecreted (sCLU), cytoplasmic/nuclear (nCLU/iCLU)
Subcellular Localization[@poon2000]
Molecular Weight80 kDa
Amino Acids522 aa
Exons9
PathwaysApoptosis, Complement, Immune Response, Mitophagy
UniProt IDP10909
NCBI Gene ID1115
Ensembl IDENSG00000120885
OMIM185551
GeneCardsCLU
Human Protein AtlasCLU
Associated Diseasesaging, Als, Alzheimer, Alzheimer Disease
InteractionsAKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, Amyloid Beta, APOE
KG Connections281 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

UniProtWikipedia

Related Hypotheses (27)

SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Aquaporin-4 Polarization Rescue
Score: 0.73
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Membrane Cholesterol Gradient Modulators
Score: 0.71
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Microglial Purinergic Reprogramming
Score: 0.70
SASP-Mediated Complement Cascade Amplification
Score: 0.70
Flotillin-1 Stabilization Compounds
Score: 0.68
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
pg 1/2Next →

Related Analyses (17)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

Related Experiments (5)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
s:** - Compare uptake with/without magnetic particles using
falsification · proposed · Score: 0.40
Proposed experiment from debate on Perivascular spaces and g
falsification · proposed · Score: 0.40
Biomechanical Impact Profiles and Chronic Traumatic Encephal
clinical · proposed · Score: 0.40
Parkinson's Disease Subtype Classification — Precision Medic
clinical · proposed · Score: 0.40

See Also (15)

Exosomal Biomarkers in Neurodegeneration
biomarker · Pages share 16 hypotheses
Exosomal miR-155 in Neurodegeneration
biomarker · Pages share 16 hypotheses
IL-6 (Interleukin-6) in Neurodegeneration
biomarker · Pages share 16 hypotheses
Liquid Biopsy in Neurodegeneration
biomarker · Pages share 16 hypotheses
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 16 hypotheses

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.