protein 2,786 words KG: CLUSTERINPROTEIN
Contents

Clusterin Protein

🔬 Protein Info
Gene SymbolCLU
Full NameClusterin
AliasesPage for CLU Gene
Chromosome8p21.1.
Protein FamilyApolipoprotein / extracellular chaperone
FunctionIt binds to non-native, misfolded, or aggregation-prone proteins and maintains them in a soluble state suitable for subsequent processing (Wyatt et al., 2009)
Primary ExpressionSecreted (sCLU), cytoplasmic/nuclear (nCLU/iCLU)
Subcellular Localization[@poon2000]
Molecular Weight80 kDa
Amino Acids522 aa
Exons9
PathwaysApoptosis, Complement, Immune Response, Mitophagy
UniProt IDP10909
NCBI Gene ID1115
Ensembl IDENSG00000120885
OMIM185551
GeneCardsCLU
Human Protein AtlasCLU
Associated Diseasesaging, Als, Alzheimer, Alzheimer Disease
InteractionsAKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, Amyloid Beta, APOE
KG Connections281 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (27)

GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
← Prevpg 2/2

Related Analyses (17)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

Related Experiments (5)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
s:** - Compare uptake with/without magnetic particles using
falsification · proposed · Score: 0.40
Proposed experiment from debate on Perivascular spaces and g
falsification · proposed · Score: 0.40
Biomechanical Impact Profiles and Chronic Traumatic Encephal
clinical · proposed · Score: 0.40
Parkinson's Disease Subtype Classification — Precision Medic
clinical · proposed · Score: 0.40

See Also (15)

Exosomal Biomarkers in Neurodegeneration
biomarker · Pages share 16 hypotheses
Exosomal miR-155 in Neurodegeneration
biomarker · Pages share 16 hypotheses
IL-6 (Interleukin-6) in Neurodegeneration
biomarker · Pages share 16 hypotheses
Liquid Biopsy in Neurodegeneration
biomarker · Pages share 16 hypotheses
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 16 hypotheses

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