protein 752 words KG: CASS4
Contents

CASS4 Protein

🔬 Protein Info
Gene SymbolCASS4
Protein FamilyCAS family (CT10 Regulated Inositol Polyphosphate 4-phosphatase Type I)
Protein TypeScaffold Protein
FunctionCASS4 participates in cellular processes
Primary Expressionneurons and immune cells
Subcellular LocalizationCytoplasmic, associated with focal adhesions
Molecular Weight49 kDa
Amino Acids442 aa
PathwaysPI3K
UniProt IDQ9H6S3
GeneCardsCASS4
Human Protein AtlasCASS4
Associated DiseasesAls, Alzheimer, Alzheimer's disease, Autoimmune, Cancer
InteractionsABCA7, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOE, App
KG Connections150 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (6)

Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

ABCA7 (Redirect)
redirect · KG edge: activates
AURKA Gene
gene · KG edge: associated_with
BIN1 — Bridging Integrator 1
gene · KG edge: activates
CASS2 — CASP2 and RIPK1 Domain Containing Adaptor
gene · KG edge: interacts_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: activates

Knowledge Graph (12 edges)

PLD3 associated_with CASS4
ABCA7 associated_with CASS4
SORL1 associated_with CASS4
PICALM associated_with CASS4
CR1 associated_with CASS4
TREM2 associated_with CASS4
CASS4 associated_with CD33
CASS4 associated_with NME8
CASS4 associated_with BIN1
CASS4 associated_with CD2AP

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