protein 1,101 words KG: CALCINEURIN
Contents

Calcineurin (PPP3CA)

🔬 Protein Info
Gene SymbolPPP3CA
AliasesProtein Phosphatase 3 Catalytic Subunit Alpha
Protein TypePhosphatase
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight58.7 kDa
Amino Acids521 aa
PathwaysAutophagy, Complement, Endocytosis, Exocytosis, Mitophagy
Ensembl IDENSG00000143510
GeneCardsPPP3CA
Human Protein AtlasPPP3CA
Associated DiseasesALS, Bipolar, Heart Failure, Schizophrenia
InteractionsALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA, AMYOTROPHIC LATERAL SCLEROSIS
KG Connections302 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (19)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.97
Transcriptional Autophagy-Lysosome Coupling
Score: 0.92
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Extracellular Matrix Stiffness Modulation
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
Cryptic Exon Silencing Restoration
Score: 0.53
Optogenetic Control of Mitochondrial Transfer Networks
Score: 0.48

Related Analyses (13)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

See Also (8)

Amyotrophic Lateral Sclerosis
redirect · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: expressed_in
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: interacts_with
Astrocytes
entity · KG edge: activates
AIFM1 Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

STIP1 activates CALCINEURIN
LGALS3 activates CALCINEURIN
HSPA8 activates CALCINEURIN
MCOLN1 activates CALCINEURIN
SQSTM1 activates CALCINEURIN
SOD1 activates CALCINEURIN
BCL2 activates CALCINEURIN
CTSB activates CALCINEURIN
TPP1 activates CALCINEURIN
GLA activates CALCINEURIN

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