concept

PPIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

1Analyses

11Outgoing

6Incoming

0Experiments

1Debates

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💡 Concept Info

Name	PPIA
Key Genes/Proteins	BAX, BCL2, MAPK1, MAPK14, MMP9, PYCARD
Related Pathways	MAPK signaling, oxidative stress response

Pathway Diagram

graph TD
    PPIA[PPIA]
    PPIA -->|inhibits| PYCARD[PYCARD]
    PPIA -->|inhibits| RAGE[RAGE]
    PPIA -->|inhibits| TLR2[TLR2]
    PPIA -->|inhibits| TLR4[TLR4]
    PPIA -->|targets| S100A9[S100A9]
    PPIA -->|targets| STAT3[STAT3]
    PPIA -->|participates in| oxidative_stress_response[oxidative stress response]
    PPIA -->|participates in| MAPK_signaling[MAPK signaling]
    PPIA -->|data_in| benchmark_ot_ad_answer_key_PPI[benchmark_ot_ad_answer_key:PPIA]
    Cyclosporine_A[Cyclosporine A] -->|inhibits| PPIA
    BCL2[BCL2] -->|inhibits| PPIA
    BAX[BAX] -->|targets| PPIA
    MAPK1[MAPK1] -->|targets| PPIA
    MAPK14[MAPK14] -->|targets| PPIA
    benchmark_ot_ad_answer_key_PPI -->|data_in| PPIA

Outgoing (11)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PPIA	data_in	dataset_row	0.00
MMP9	activates	protein	0.70
RAGE	inhibits	gene	0.60
TLR2	inhibits	gene	0.60
TLR4	inhibits	gene	0.60
S100A9	targets	gene	0.60
PYCARD	inhibits	gene	0.60
TLR4	targets	gene	0.60
oxidative stress response	participates_in	pathway	0.60
MAPK signaling	participates_in	pathway	0.60
STAT3	targets	gene	0.60

Incoming (6)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:PPIA	data_in	dataset_row	0.00
Cyclosporine A	inhibits	drug	0.95
BCL2	inhibits	gene	0.60
BAX	targets	gene	0.60
MAPK1	targets	gene	0.60
MAPK14	targets	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does pericyte senescence drive BBB breakdown or result from neurodegeneration as

neurodegeneration | 2026-04-25 | 6 hypotheses Top: 0.720

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Does pericyte senescence drive BBB breakdown or result from neurodegeneration as

closed · Rounds: 4 · Score: 0.68 · 2026-04-25

Related Research

Hypotheses and analyses mentioning PPIA in their description or question text

No additional research found