| Gene Symbol | NLRP3 |
| Protein Type | Signaling Protein |
| Target Class | Signaling Protein |
| Function | In the healthy nervous system, NLRP3: - Provides innate immune surveillance - Responds to pathogen-associated molecular patterns (PAMPs) - Initiates inflammatory responses to cellular stress - Facilit |
| Mechanism of Action | Small molecule inhibitors targeting NLRP3 inflammasome assembly or activation |
| Subcellular Localization | </th><td>Cytoplasm, inflammasome complex</td></tr> |
| Druggability | Medium (0.51) |
| Clinical Stage | Approved |
| Molecular Weight | 118 kDa |
| Pathways | Adaptive Immunity, Ampk Signaling, Amyloid, Apoptosis, Autophagy |
| UniProt ID | A0A7I2R3P8 |
| GeneCards | NLRP3 |
| Human Protein Atlas | NLRP3 |
| PYD (N-terminal) | Pyrin domain for homotypic interactions with ASC |
| NACHT | Central nucleotide-binding domain responsible for oligomerization and ATP hydrolysis |
| Associated Diseases | acute gouty arthritis, AD, Aging, ALI, Als |
| Known Drugs/Compounds | 1,25(OH)2D, 1-deoxysphingolipids, Ams-17, Asiaticoside, Aucubin, Berberine |
| Interactions | ABCA1, ABCA7, ABCD3, ACE2, ACHE, acid sphingomyelinase |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | NLRP3 inflammasome amplification across AD and PD NLRP3/Mitophagy Coupling Modulation NLRP3 Inflammasome Inhibition Prevents Synapse Los (+6 more) |
| KG Connections | 4770 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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