| Gene Symbol | MMP2 |
| Full Name | Matrix Metallopeptidase 2 |
| Chromosome | 16q13 |
| Protein Type | Protease |
| Target Class | Protease |
| Function | MMP-2 (gelatinase A) degrades gelatin (denatured collagen), type IV collagen, and elastin. |
| Mechanism of Action | Small molecule zinc-chelating inhibitors of metalloprotease activity |
| Primary Expression | neurons, astrocytes, microglia, and endothelial cells where it regulates synaptic plasticity, blood-brain |
| Druggability | Medium (0.46) |
| Clinical Stage | Phase III |
| Molecular Weight | 73.9 kDa |
| Amino Acids | 660 aa |
| Pathways | Akt, Amyloid, Nf-Κb, Pi3K, Sleep-Wake Cycle |
| UniProt ID | P08253 |
| Ensembl ID | ENSG00000196547 |
| GeneCards | MMP2 |
| Human Protein Atlas | MMP2 |
| Associated Diseases | aging, Als, Alzheimer, Alzheimer's disease |
| Known Drugs/Compounds | Melatonin |
| Interactions | ADAMTS1, AEP, AGING, AGO2, AKT, AKT1 |
| SciDEX Target | View Target Profile (5 clinical trials) |
| KG Connections | 792 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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