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mechanism 1,457 words KG: PSP
Contents

Eye Movement Abnormalities in Corticobasal Syndrome

⚙ Mechanism Info
NamePSP
Key Genes/Proteins4R-tau, ABCA7, Actin, AGING, AKT, ALZHEIMER
Related DiseasesAging, Als, ALS, Alzheimer, Alzheimer's disease
Related PathwaysAkt

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Related Hypotheses (28)

Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78CYP46A1 Overexpression Gene Therapy
Score: 0.77Circadian Clock-Autophagy Synchronization
Score: 0.76Smartphone-Detected Motor Variability Correction
Score: 0.74Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72Retinal Vascular Microcirculation Rescue
Score: 0.72Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71Noradrenergic-Tau Propagation Blockade
Score: 0.71Autophagosome Maturation Checkpoint Control
Score: 0.71Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70Microglial Purinergic Reprogramming
Score: 0.70Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70Axonal RNA Transport Reconstitution
Score: 0.70Ocular Immune Privilege Extension
Score: 0.69Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67Nucleolar Stress Response Normalization
Score: 0.65
pg 1/2Next →

Related Analyses (30)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

Knowledge Graph (12 edges)

DUSP10 associated_with PSP
MAP1S associated_with PSP
PSP associated_with SP1
PSP associated_with APOE
PSP associated_with TAU
PSP associated_with KIF13A
PSP associated_with TRIM24
PSP associated_with STX6
PSP associated_with MAPT
TAU activates PSP

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