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mechanism 1,502 words KG: PSP
Contents

lipid-metabolism-psp

⚙ Mechanism Info
NamePSP
Key Genes/ProteinsABCA7, Actin, AGING, AKT, ALZHEIMER, ALZHEIMER DISEASE
Related DiseasesAging, Als, ALS, Alzheimer, Alzheimer's disease
Related PathwaysAkt, Amyloid

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Related Hypotheses (107)

ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.87AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76Transcriptional Autophagy-Lysosome Coupling
Score: 0.76GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.75Senescent Cell Mitochondrial DNA Release
Score: 0.74APOE-TREM2 Interaction Modulation
Score: 0.74CYP46A1 Overexpression Gene Therapy
Score: 0.73Adenosine-Astrocyte Metabolic Reset
Score: 0.73Phase-Separated Organelle Targeting
Score: 0.73Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72
← Prevpg 2/6Next →

Related Analyses (11)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedCRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archivedExtracellular vesicle biomarkers for early AD detection
neurodegeneration · archivedAutophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archivedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived

Knowledge Graph (12 edges)

DUSP10 associated_with PSP
MAP1S associated_with PSP
PSP associated_with SP1
PSP associated_with APOE
PSP associated_with TAU
PSP associated_with KIF13A
PSP associated_with TRIM24
PSP associated_with STX6
PSP associated_with MAPT
TAU activates PSP

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