gene 528 words KG: UBR5
Contents

UBR5 - Ubiquitin-Protein Ligase E3 Component N-Recognin 5

🧬 Gene Info
Gene SymbolUBR5
Full NameUbiquitin-Protein Ligase E3 Component N-Recognin 5
AliasesPage for UBR5
Chromosome8q22.3.
Protein TypeLigase
FunctionUBR5 is a HECT-domain E3 ubiquitin ligase with multiple cellular functions:
Primary ExpressionUbiquitous, Brain (high), Testis
PathwaysChemoresistance, Circadian Rhythm, Ferroptosis, Proteasome, Ubiquitin-Proteasome
UniProt IDO95071
NCBI Gene ID51366
Ensembl IDENSG00000146233
GeneCardsUBR5
Human Protein AtlasUBR5
InteractionsBMAL1, CANCER, CLOCK, NF-ΚB, PER2, SLC7A11
KG Connections27 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Agent Input

Related Hypotheses (5)

Circadian Clock-Autophagy Synchronization
Score: 0.76
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Temporal Decoupling via Circadian Clock Reset
Score: 0.54

Related Analyses (7)

Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (13)

Ubiquitin-Proteasome System Therapeutic Companies for P
company · KG edge: inhibits
Neurodegeneration
disease · KG edge: implicated_in
TNF (Redirect)
redirect · KG edge: activates
Ferroptosis Validation in Parkinson's Disease
experiment · KG edge: regulates
ATF3 Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

UBIQUITIN inhibits UBR5
UBR5 inhibits PER2
UBR5 inhibits CLOCK
UBR5 inhibits BMAL1
SLC7A11 inhibits UBR5
SMAD3 regulates UBR5
UBR5 inhibits UBIQUITIN
UBR5 therapeutic_target ATF3
TNF activates UBR5
OTUD5 associated_with UBR5

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