| Gene Symbol | TGFB1 |
| Full Name | Transforming Growth Factor Beta 1 |
| Chromosome | 19q13.2 |
| Protein Type | Ligand |
| Target Class | Ligand |
| Function | encodes Transforming Growth Factor Beta 1, a key cytokine with complex roles in neuroinflammation, neuroprotection, and synaptic plasticity |
| Mechanism of Action | Monoclonal antibodies neutralizing TGF-β1 or small molecule inhibitors of TGF-β signaling |
| Druggability | Low (0.44) |
| Clinical Stage | Phase III |
| Amino Acids | 390 aa |
| Gene Type | Protein coding |
| Pathways | Autophagy, Immune Response, Mtor, Tgf-Β |
| UniProt ID | P01137 |
| Ensembl ID | ENSG00000127616 |
| GeneCards | TGFB1 |
| Human Protein Atlas | TGFB1 |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer's disease, Cancer |
| Known Drugs/Compounds | curcumin, resveratrol |
| Interactions | ACTB, AHR, AHSA1, ALZHEIMER, AND, APP |
| SciDEX Target | View Target Profile (8 clinical trials) |
| KG Connections | 722 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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