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gene 909 words KG: SYK
Contents

SYK Gene

🧬 Gene Info
Gene SymbolSYK
Chromosome9q22
Protein FamilySrc family tyrosine kinases
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionbrain microglia (Iba1+ cells) - Increased expression in disease states - Localizes to amyloid plaques in AD
Molecular Weight72 kDa
Amino Acids629 aa
Exons18
PathwaysPI3K, MAPK
UniProt IDP43405
NCBI Gene ID6715
GeneCardsSYK
Human Protein AtlasSYK
Associated DiseasesALS, Alzheimer, CYTOKINES, PYROPTOSIS
Known Drugs/CompoundsEntospletinib, metformin, Pustulan, R406
InteractionsAIM2, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND
KG Connections359 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (20)

APOE-Dependent Autophagy Restoration
Score: 0.88Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74APOE-TREM2 Interaction Modulation
Score: 0.74CYP46A1 Overexpression Gene Therapy
Score: 0.73Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Orexin-Microglia Modulation Therapy
Score: 0.71Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67TREM2-mediated microglial tau clearance enhancement
Score: 0.62TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58TREM2-Dependent Microglial Senescence Transition
Score: 0.58

Related Analyses (9)

Does SYK activation provide neuroprotection or exacerbate ne
neurodegeneration · archivedTREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completedWhich cell types show the most significant expression change
neurodegeneration · completedMechanistic role of APOE in neurodegeneration
neurodegeneration · archivedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (1)

Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40

See Also (10)

ABCA7 (Redirect)
redirect · KG edge: regulatesAMPK (AMP-Activated Protein Kinase)
entity · KG edge: regulatesApoptosis in Neurodegeneration
entity · KG edge: activatesAmyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activatesASC (PYCARD)
gene · KG edge: activates

Knowledge Graph (12 edges)

SYK activates TREM2
SYK co_discussed TREM2
AKT associated_with SYK
PI3K associated_with SYK
APOE associated_with SYK
SYK associated_with TFEB
SYK associated_with TREM2
TREM2 expressed_in SYK
IL6 expressed_in SYK
IL1B expressed_in SYK

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