gene 749 words KG: STAR
Contents

STAR — Steroidogenic Acute Regulatory Protein

🧬 Gene Info
Gene SymbolSTAR
Full NameSteroidogenic Acute Regulatory Protein
AliasesSTART1, STARD1
Chromosome8p11.23
FunctionCholesterol accumulates at mitochondria-ER contact sites
Primary ExpressionBrain (neurons, glia), adrenal gland, gonads
Amino Acids285 aa
PathwaysAngiogenesis, Apoptosis, Mtor, Pi3K/Akt, Synaptic Plasticity
UniProt IDP49675
NCBI Gene ID6779
Ensembl IDENSG00000147548
GeneCardsSTAR
Human Protein AtlasSTAR
C-terminal regulatory regionContains phosphorylation sites
Associated DiseasesAging, Als, Alzheimer, Cancer, Inflammation, Neurodegeneration
InteractionsAKT, ALZHEIMER, AND, APOPTOSIS, App, ASTROCYTE
KG Connections179 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (80)

Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.72
Stress Granule Phase Separation Modulators
Score: 0.72
Retinal Vascular Microcirculation Rescue
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
Noradrenergic-Tau Propagation Blockade
Score: 0.71
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.71
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Axonal RNA Transport Reconstitution
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Ocular Immune Privilege Extension
Score: 0.69
Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69
Ganglioside Rebalancing Therapy
Score: 0.69
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
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Related Analyses (29)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (14)

Experiment Validation: In vitro ThT Assay
validation · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40

See Also (12)

Astrocytes
cell · KG edge: activates
ATP P2X3 Receptor Neurons
cell · KG edge: inhibits
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: expressed_in
Apoptosis in Neurodegeneration
entity · KG edge: inhibits
Astrocytes
entity · KG edge: activates

Knowledge Graph (12 edges)

CD8 expressed_in STAR
CD4 expressed_in STAR
GAIN inhibits STAR
PP2A associated_with STAR
STAR expressed_in CD8
STAR associated_with PP2A
STAR inhibits GAIN
CD4 associated_with STAR
CD8 associated_with STAR
BAX expressed_in STAR

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