gene 749 words KG: STAR
Contents

STAR — Steroidogenic Acute Regulatory Protein

🧬 Gene Info
Gene SymbolSTAR
Full NameSteroidogenic Acute Regulatory Protein
AliasesSTART1, STARD1
Chromosome8p11.23
FunctionCholesterol accumulates at mitochondria-ER contact sites
Primary ExpressionBrain (neurons, glia), adrenal gland, gonads
Amino Acids285 aa
PathwaysAngiogenesis, Apoptosis, Mtor, Pi3K/Akt, Synaptic Plasticity
UniProt IDP49675
NCBI Gene ID6779
Ensembl IDENSG00000147548
GeneCardsSTAR
Human Protein AtlasSTAR
C-terminal regulatory regionContains phosphorylation sites
Associated DiseasesAging, Als, Alzheimer, Cancer, Inflammation, Neurodegeneration
InteractionsAKT, ALZHEIMER, AND, APOPTOSIS, App, ASTROCYTE
KG Connections179 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (80)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
Transcriptional Autophagy-Lysosome Coupling
Score: 0.88
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.84
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.78
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Multi-Modal Stress Response Harmonization
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Smartphone-Detected Motor Variability Correction
Score: 0.74
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Phase-Separated Organelle Targeting
Score: 0.73
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
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Related Analyses (29)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (14)

Experiment Validation: In vitro ThT Assay
validation · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40

See Also (12)

Astrocytes
cell · KG edge: activates
ATP P2X3 Receptor Neurons
cell · KG edge: inhibits
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: expressed_in
Apoptosis in Neurodegeneration
entity · KG edge: inhibits
Astrocytes
entity · KG edge: activates

Knowledge Graph (12 edges)

CD8 expressed_in STAR
CD4 expressed_in STAR
GAIN inhibits STAR
PP2A associated_with STAR
STAR expressed_in CD8
STAR associated_with PP2A
STAR inhibits GAIN
CD4 associated_with STAR
CD8 associated_with STAR
BAX expressed_in STAR

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