gene 749 words KG: STAR
Contents

STAR — Steroidogenic Acute Regulatory Protein

🧬 Gene Info
Gene SymbolSTAR
Full NameSteroidogenic Acute Regulatory Protein
AliasesSTART1, STARD1
Chromosome8p11.23
FunctionCholesterol accumulates at mitochondria-ER contact sites
Primary ExpressionBrain (neurons, glia), adrenal gland, gonads
Amino Acids285 aa
PathwaysAngiogenesis, Apoptosis, Mtor, Pi3K/Akt, Synaptic Plasticity
UniProt IDP49675
NCBI Gene ID6779
Ensembl IDENSG00000147548
GeneCardsSTAR
Human Protein AtlasSTAR
C-terminal regulatory regionContains phosphorylation sites
Associated DiseasesAging, Als, Alzheimer, Cancer, Inflammation, Neurodegeneration
InteractionsAKT, ALZHEIMER, AND, APOPTOSIS, App, ASTROCYTE
KG Connections179 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (80)

Cross-Seeding Prevention Strategy
Score: 0.69
Hypocretin-Neurogenesis Coupling Therapy
Score: 0.69
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68
Osmotic Gradient Restoration via Selective AQP1 Enhancement
Score: 0.68
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A
Score: 0.67
Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli
Score: 0.67
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
Complement C1q Subtype Switching
Score: 0.66
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
Microbial Inflammasome Priming Prevention
Score: 0.65
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Synthetic Biology Rewiring via Orthogonal Receptors
Score: 0.65
Ephrin-B2/EphB4 Axis Manipulation
Score: 0.64
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
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Related Analyses (29)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (14)

Experiment Validation: In vitro ThT Assay
validation · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40

See Also (12)

Astrocytes
cell · KG edge: activates
ATP P2X3 Receptor Neurons
cell · KG edge: inhibits
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: expressed_in
Apoptosis in Neurodegeneration
entity · KG edge: inhibits
Astrocytes
entity · KG edge: activates

Knowledge Graph (12 edges)

CD8 expressed_in STAR
CD4 expressed_in STAR
GAIN inhibits STAR
PP2A associated_with STAR
STAR expressed_in CD8
STAR associated_with PP2A
STAR inhibits GAIN
CD4 associated_with STAR
CD8 associated_with STAR
BAX expressed_in STAR

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