gene 1,483 words KG: SIGLEC1
Contents

SIGLEC1 Gene

🧬 Gene Info
Gene SymbolSIGLEC1
Full NameSialic Acid-Binding Ig-Like Lectin 1
Chromosome20p13
Protein TypeReceptor
FunctionSialic Acid Recognition: Binds to sialylated glycans on host cells and pathogens
Molecular Weight185 kDa
Amino Acids1644 aa
UniProt ID[Q9PMN3](https://www.uniprot.org/uniprot/Q9PMN3)
Ensembl IDENSG00000105550
OMIM600738
GeneCardsSIGLEC1
Human Protein AtlasSIGLEC1
N-terminal V-type Ig domainContains the sialic acid-binding site
C2-type Ig domains (16 repeats)Form the stalk region
Mucin-like regionProvides extended structure
Associated Diseasesneurodegeneration
KG Connections45 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (11)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
TREM2-mediated microglial tau clearance enhancement
Score: 0.62

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

JAK Inhibitors in Parkinson's Disease
company · KG edge: therapeutic_target
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: co_discussed
SORL1 (Redirect)
redirect · KG edge: co_discussed
TREM2 Protein (Triggering Receptor Expressed on Myeloid
entity · KG edge: co_discussed
GRN Carrier Resilience: Why Some Mutation Carriers Rema
general · KG edge: co_discussed

Knowledge Graph (12 edges)

MAPK10 associated_with SIGLEC1
APOE therapeutic_target SIGLEC1
SIGLEC1 therapeutic_target SPR
SIGLEC1 therapeutic_target APOE
SIGLEC1 associated_with MAPK10
APOE co_discussed SIGLEC1
APP co_discussed SIGLEC1
BIN1 co_discussed SIGLEC1
CD2AP co_discussed SIGLEC1
CLU co_discussed SIGLEC1

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