| Gene Symbol | SERPINA3 |
| Full Name | Serpin Family A Member 3 |
| Aliases | Alpha-1 Antichymotrypsin in Neurodegeneration |
| Chromosome | 14q32.13 |
| Protein Type | Protease |
| Function | Limits protease-mediated tissue damage during inflammation |
| Primary Expression | Brain (astrocytes), liver, lung, immune cells |
| Molecular Weight | 47 kDa |
| Amino Acids | 418 aa |
| Pathways | MAPK signaling, lipid metabolism, oxidative stress response |
| UniProt ID | [P01011](https://www.uniprot.org/uniprot/P01011) |
| GeneCards | SERPINA3 |
| Human Protein Atlas | SERPINA3 |
| N-terminal signal peptide | Secretory pathway targeting |
| Serpin domain | The characteristic serpin fold with reactive center loop (RCL) |
| Associated Diseases | Alzheimer, Alzheimer's Disease, dementia, Inflammation, neurodegeneration |
| Interactions | ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APOE, APOE4, ASTROCYTE |
| KG Connections | 168 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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