| Gene Symbol | PRKDC |
| Full Name | DNA-Dependent Protein Kinase Catalytic Subunit |
| Chromosome | 8q13-q21 |
| Protein Family | PI3/PI4-related kinase family |
| Function | DNA damage detection: Ku70/Ku80 heterodimer binds DSB ends |
| Primary Expression | neurons and glia throughout the CNS: |
| Molecular Weight | 469 kDa |
| Amino Acids | 128 aa |
| Pathways | Autophagy |
| UniProt ID | [P78527](https://www.uniprot.org/uniprot/P78527) |
| Ensembl ID | ENSG00000151067 |
| OMIM | 300123 |
| GeneCards | PRKDC |
| Human Protein Atlas | PRKDC |
| V(D)J recombination | Essential for lymphocyte development |
| Associated Diseases | Tumor |
| Interactions | AMPK, ATG5, BECN1, CAMK2, CANCER, CASP3 |
| KG Connections | 51 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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