| Gene Symbol | NLRX1 |
| Chromosome | 6q16.1 |
| Protein Type | Receptor |
| Function | Upon detection of viral RNA in the cytosol, NLRX1 interacts with MAVS (Mitochondrial Antiviral Signaling Protein) to enhance downstream NF-κB and IRF activation, leading to production of type I interf |
| Primary Expression | multiple tissues, including the brain, where it is found in neurons, astrocytes, and [microglia](/cell-ty |
| Molecular Weight | 103 kDa |
| Amino Acids | 977 aa |
| Pathways | NF-κB |
| UniProt ID | Q9NWV8 |
| NCBI Gene ID | 79671 |
| Ensembl ID | ENSG00000170873 |
| GeneCards | NLRX1 |
| Human Protein Atlas | NLRX1 |
| N-terminal pyrin domain (PYD) | Mediates homotypic interactions with other PYD-containing |
| NACHT domain | Central ATPase domain that drives oligomerization and activation |
| Associated Diseases | Parkinson |
| Interactions | ABP, ATG16L1, BCL2, CALCOCO2, CASP3, DMSO |
| KG Connections | 75 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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