gene 1,644 words KG: NFE2L2
Contents

NFE2L2 — Nuclear Factor Erythroid 2-Related Factor 2

🧬 Gene Info
Gene SymbolNFE2L2
Full NameNuclear Factor Erythroid 2-Related Factor 2
Chromosome2q31
Protein FamilybZIP transcription factor family, Cap'n'collar subfamily
PathwaysAutophagy, Chaperone, Epigenetic, Ferroptosis, Glutathione Synthesis
UniProt IDQ16236
NCBI Gene ID4780
Ensembl IDENSG00000116044
OMIM604992
GeneCardsNFE2L2
Human Protein AtlasNFE2L2
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Cancer, Carcinoma, Hepatomegaly, Hepatoprotection
Known Drugs/Compoundsdexamethasone, Dimethyl Fumarate, Itaconate, Leucocyanidin, Ml385, Pterostilbene
InteractionsACOX1, ACTB, Adiponectin, ADIPOQ, AGING, AKT
KG Connections852 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (26)

Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Microbial Inflammasome Priming Prevention
Score: 0.65
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
← Prevpg 2/2

Related Analyses (12)

Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (16)

Resveratrol protection against renal I/R injury in diabetic
validation · proposed · Score: 0.90
Resveratrol effects on HK-2 cells under hypoxia/reoxygenatio
exploratory · proposed · Score: 0.85
Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (7)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
ACTB Gene
gene · KG edge: causes
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: therapeutic_target
ALOX15 - Arachidonate 15-Lipoxygenase
gene · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates

Knowledge Graph (12 edges)

VDR activates NFE2L2
NFE2L2 activates HMOX1
NFE2L2 inhibits ferroptosis
SQSTM1 activates NFE2L2
KEAP1 inhibits NFE2L2
ALOX5 activates NFE2L2
HMOX1 activates NFE2L2
ALOX15 activates NFE2L2
ALOX12 activates NFE2L2
NFE2L2 activates FER

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