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gene 1,644 words KG: NFE2L2
Contents

NFE2L2 — Nuclear Factor Erythroid 2-Related Factor 2

🧬 Gene Info
Gene SymbolNFE2L2
Full NameNuclear Factor Erythroid 2-Related Factor 2
Chromosome2q31
Protein FamilybZIP transcription factor family, Cap'n'collar subfamily
PathwaysAutophagy, Chaperone, Epigenetic, Ferroptosis, Glutathione Synthesis
UniProt IDQ16236
NCBI Gene ID4780
Ensembl IDENSG00000116044
OMIM604992
GeneCardsNFE2L2
Human Protein AtlasNFE2L2
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Cancer, Carcinoma, Hepatomegaly, Hepatoprotection
Known Drugs/Compoundsdexamethasone, Dimethyl Fumarate, HBOT, Itaconate, Leucocyanidin, Ml385
InteractionsACOX1, ACTB, Adiponectin, ADIPOQ, AGING, AKT
KG Connections859 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (26)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56APOE-Dependent Autophagy Restoration
Score: 0.89AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.83Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78Transcriptional Autophagy-Lysosome Coupling
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76Multi-Modal Stress Response Harmonization
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71Autophagosome Maturation Checkpoint Control
Score: 0.71
pg 1/2Next →

Related Analyses (12)

Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archivedMicroglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archivedWhat are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completedMechanistic role of APOE in neurodegeneration
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (16)

Resveratrol protection against renal I/R injury in diabetic
validation · proposed · Score: 0.90Resveratrol effects on HK-2 cells under hypoxia/reoxygenatio
exploratory · proposed · Score: 0.85Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (7)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activatesACTB Gene
gene · KG edge: causesADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: therapeutic_targetALOX15 - Arachidonate 15-Lipoxygenase
gene · KG edge: activatesAlzheimer Indonesia
institution · KG edge: activates

Knowledge Graph (12 edges)

VDR activates NFE2L2
NFE2L2 activates HMOX1
NFE2L2 inhibits ferroptosis
SQSTM1 activates NFE2L2
KEAP1 inhibits NFE2L2
ALOX5 activates NFE2L2
HMOX1 activates NFE2L2
ALOX15 activates NFE2L2
ALOX12 activates NFE2L2
NFE2L2 activates FER

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