| Gene Symbol | MMP7 |
| Full Name | Matrix Metalloproteinase 7 |
| Aliases | Page for MMP7 |
| Function | MMP7 (Matrix Metallopeptidase 7), also known as matrilysin, is a unique member of the MMP family characterized by its small size and specific substrate profile. |
| Primary Expression | Paneth cells and mucous membranes, where it generates antimicrobial peptides from precursors, providing innate immune protection |
| Pathways | oxidative stress response |
| Ensembl ID | ENSG00000137673 |
| GeneCards | MMP7 |
| Human Protein Atlas | MMP7 |
| Extracellular Matrix Remodeling | MMP7 degrades elastin, casein, gelatin, and non-helical collagen. Unlike other MMPs, it does not degrade triple-helical collagen. |
| Antimicrobial Defense | MMP7 is expressed in Paneth cells and mucous membranes, where it generates antimicrobial peptides from precursors, providing innate immune protection. |
| Wound Healing | The protease promotes re-epithelialization and keratinocyte migration during tissue repair. |
| Associated Diseases | ALS |
| Interactions | App, CD4, COL6A1, Proteins, Ras |
| KG Connections | 43 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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