| Gene Symbol | CHN1 |
| Full Name | Chimerin 1 |
| Chromosome | 2q31.1 |
| Protein Family | Rho GTPase-activating proteins (RhoGAPs) |
| Function | Alpha-1-chimaerin is expressed predominantly in the nervous system and functions as a critical regulator of Rho GTPase signaling. |
| Primary Expression | Neuron-specific, high in brain and peripheral nervous system |
| UniProt ID | P15884 |
| NCBI Gene ID | 1123 |
| GeneCards | CHN1 |
| Human Protein Atlas | CHN1 |
| Actin cytoskeleton dynamics | Rac1 controls the formation of actin-rich structures including lamellipodia, filopodia, and dendritic spines |
| Cell adhesion | Rac1 regulates integrin-mediated adhesion to the extracellular matrix |
| Cytokinesis | Rac1 plays roles in cell division during development |
| Dendritic morphogenesis | CHN1 regulates Rac1 activity to control dendritic arborization and spine formation[@rac2007] |
| Axon guidance | Rac1 signaling influences growth cone dynamics and pathfinding during axon extension |
| Associated Diseases | Alzheimer, Amyotrophic Lateral Sclerosis, disease, neurodegeneration, Neurodegenerative Diseases, Parkinson |
| KG Connections | 38 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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