| Gene Symbol | MAP1A |
| Chromosome | 15q15.2. |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 250 kDa |
| Amino Acids | 248 aa |
| Pathways | NF-kB signaling |
| Ensembl ID | ENSG00000118789 |
| GeneCards | MAP1A |
| Human Protein Atlas | MAP1A |
| [Cortex](/brain-regions/cortex) | Strong expression in layer II-III pyramidal neurons |
| Cerebellum | Abundant in Purkinje cells and granule cells |
| Basal ganglia | Moderate expression in striatal medium spiny neurons |
| Brainstem | Present in various nuclei including the locus coeruleus |
| Microtubule Stabilization | Promotes microtubule assembly and prevents depolymerization, essential for maintaining axonal integrity |
| Axonal Transport Facilitation | Functions as a molecular scaffold for motor protein complexes, enabling efficient transport of vesicles, organelles, and signaling molecules along microtubules |
| Associated Diseases | neurodegeneration |
| Interactions | MAP1B, MAP2, MAP6 |
| KG Connections | 17 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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