| Gene Symbol | KEAP1 |
| Full Name | Kelch-Like ECH-Associated Protein 1 |
| Aliases | Page for KEAP1 |
| Protein Type | Adaptor Protein |
| Function | High-Affinity Binding: ETGE motif of NRF2 binds to one Kelch domain (hinge) |
| Subcellular Localization | </th><td>Cytoplasm, Cytoskeleton</td></tr> |
| Molecular Weight | 70 kDa |
| Amino Acids | 624 aa |
| Pathways | Akt, Apoptosis, Autophagy, Cell Cycle, Differentiation |
| UniProt ID | Q14145 |
| GeneCards | KEAP1 |
| Human Protein Atlas | KEAP1 |
| N-terminal region | Interacts with NRF2 |
| Intermediate region (IVR) | Contains reactive cysteine residues |
| Kelch repeat domain | Binds NRF2 Neh2 domain |
| Associated Diseases | Aging, Als, Alzheimer, AUTOPHAGY, Cancer |
| Known Drugs/Compounds | DOXORUBICIN, Epalrestat, EPALRESTAT, EPS, Fumarate, gastrodin |
| Interactions | ACHE, ACOD1, Actin, AD, AGING, AIFM1 |
| KG Connections | 1194 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!