gene 1,374 words KG: KCNN4
Contents

KCNN4 — Potassium Calcium-Activated Channel Subfamily N Member 4

🧬 Gene Info
Gene SymbolKCNN4
Full NamePotassium Calcium-Activated Channel Subfamily N Member 4
AliasesSK4, IK1, Small Conductance Calcium-Activated Potassium Channel 4
Chromosome19q13.2
Protein TypeIon channel (intermediate-conductance Ca²⁺-activated K⁺)
Functionis an intermediate-conductance calcium-activated potassium channel that plays critical roles in immune cell activation, erythrocyte volume regulation, epithelial secretion, and neuroinflammation.
Primary ExpressionErythrocytes, immune cells, brain (glia), salivary glands
Molecular Weight71 kDa
PathwaysInteraction
UniProt IDQ9UQM4
NCBI Gene ID3782
Ensembl IDENSG00000104970
OMIM604270
GeneCardsKCNN4
Human Protein AtlasKCNN4
Associated DiseasesCancer
InteractionsAPOPTOSIS, CYTOKINES, NEURON, Ras, RNA
KG Connections125 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (7)

Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
PARP1 Inhibition Therapy
Score: 0.74
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Extracellular Matrix Stiffness Modulation
Score: 0.69
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65

Related Analyses (7)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (12)

blarcamesine-axon
clinical_trial · KG edge: associated_with
Apoptosis in Neurodegeneration
entity · KG edge: activates
Genes
index · KG edge: associated_with
CACNA1B Gene
gene · KG edge: causes
CACNA1C Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

PIEZO1 associated_with KCNN4
KCNK2 associated_with KCNN4
SCN5A associated_with KCNN4
TRPM7 associated_with KCNN4
SCN1A associated_with KCNN4
TRPV4 associated_with KCNN4
CACNA1B associated_with KCNN4
SCNN1A associated_with KCNN4
CFTR associated_with KCNN4
PIEZO2 associated_with KCNN4

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