| Gene Symbol | GSK3B |
| Full Name | Glycogen Synthase Kinase 3 Beta |
| Aliases | GSK-3β, TPKII, Tau tubulin kinase (TTBK) |
| Chromosome | 3q13.33 |
| Protein Type | Serine/Threonine Kinase |
| Function | is a constitutively active serine/threonine kinase encoded by the GSK3B gene that plays central and multifaceted roles in cellular physiology[@woodgett1990]. |
| Molecular Weight | 47 kDa (420 amino acids) |
| Amino Acids | 420 aa |
| Exons | 12 |
| Pathways | Akt, Cholesterol, Mapk, Microrna, Nf-Kb |
| GeneCards | GSK3B |
| Human Protein Atlas | GSK3B |
| Wnt signaling | GSK3B is a key component of the Wnt/β-catenin pathway, where it phosphorylates β-catenin targeting it for degradation<sup>[2]</sup> |
| Glycogen metabolism | Originally identified as a regulator of glycogen synthase, hence its name |
| Synaptic plasticity | GSK3B regulates NMDA receptor trafficking, AMPA receptor internalization, and long-term potentiation (LTP)<sup>[3]</sup> |
| Associated Diseases | Aging, ALS, Alzheimer, Alzheimer's disease, APOPTOSIS |
| Known Drugs/Compounds | ANTHOCYANINS, Ficus deltoidea, LITHIUM, rapamycin, RAPAMYCIN, SB216763 |
| Interactions | ABCA1, ACETYL-COA, ACHE, Actin, AD, ADAM17 |
| KG Connections | 1182 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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