gene 2,009 words KG: GPX1
Contents

GPX1 — Glutathione Peroxidase 1

🧬 Gene Info
Gene SymbolGPX1
Full NameGlutathione Peroxidase 1
Chromosome3p21.31
Protein TypeSelenoprotein, Antioxidant enzyme
Functionis a gene located on chromosome 3p21.
Molecular Weight22.5 kDa
Amino Acids203 aa
Exons2
PathwaysEpigenetic, Mitochondrial Function, Oxidative Stress
UniProt IDP07203
NCBI Gene ID2783
Ensembl IDENSG00000133247
OMIM138320
GeneCardsGPX1
Human Protein AtlasGPX1
Associated DiseasesAls, Alzheimer, ALZHEIMER'S DISEASE, Inflammation, Ms
InteractionsAGING, ALZHEIMER'S DISEASE, AND, ANTIOXIDANT GENES, APOPTOSIS, APP
KG Connections164 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (16)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.94
Transcriptional Autophagy-Lysosome Coupling
Score: 0.90
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.85
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.81
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Extracellular Matrix Stiffness Modulation
Score: 0.69
Piezoelectric Nanochannel BBB Disruption
Score: 0.52

Related Analyses (4)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (18)

Purinergic Signaling Dysfunction Validation in Parkinson's D
clinical · proposed · Score: 0.40
Regulated Necrosis Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Stress Granule Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Experiment Validation: In vitro ThT Assay
validation · proposed · Score: 0.40

See Also (10)

Apoptosis in Neurodegeneration
entity · KG edge: activates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: activates
BAX Gene
gene · KG edge: expressed_in
BDNF Gene
gene · KG edge: activates
CAT — Catalase
gene · KG edge: activates

Knowledge Graph (12 edges)

BAX expressed_in GPX1
SOD2 activates GPX1
STAR activates GPX1
CAT activates GPX1
PPARA associated_with GPX1
SOD2 associated_with GPX1
GPX1 associated_with PPARG
NOX4 activates GPX1
SOD1 activates GPX1
GPX1 activates NRF2

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